Mastermind supports GRCh37 and GRCh38 searches for SNVs/indels. Variants can be entered directly in the search box as shown below in GRCh37 and GRCh38, respectively:
NC_000001.10:g.94508323G>A
NC_000001.11:g.94042767G>A
To search for genomic coordinates in Mastermind, enter them in the search bar with the appropriate sequence identifier or modify the URL directly as in the example link below.
https://mastermind.genomenon.com/detail?mutation=(add chromosome here):g.94508323G>A
where (add chromosome here) can be taken from the list below and substituted into the URL.
Chromosome | GRCh37/hg19 | GRCh38/hg38 |
---|---|---|
1 | NC_000001.10 | NC_000001.11 |
2 | NC_000002.11 | NC_000002.12 |
3 | NC_000003.11 | NC_000003.12 |
4 | NC_000004.11 | NC_000004.12 |
5 | NC_000005.9 | NC_000005.10 |
6 | NC_000006.11 | NC_000006.12 |
7 | NC_000007.13 | NC_000007.14 |
8 | NC_000008.10 | NC_000008.11 |
9 | NC_000009.11 | NC_000009.12 |
10 | NC_000010.10 | NC_000010.11 |
11 | NC_000011.9 | NC_000011.10 |
12 | NC_000012.11 | NC_000012.12 |
13 | NC_000013.10 | NC_000013.11 |
14 | NC_000014.8 | NC_000014.9 |
15 | NC_000015.9 | NC_000015.10 |
16 | NC_000016.9 | NC_000016.10 |
17 | NC_000017.10 | NC_000017.11 |
18 | NC_000018.9 | NC_000018.10 |
19 | NC_000019.9 | NC_000019.10 |
20 | NC_000020.10 | NC_000020.11 |
21 | NC_000021.8 | NC_000021.9 |
22 | NC_000022.10 | NC_000022.11 |
X | NC_000023.10 | NC_000023.11 |
Y | NC_000024.9 | NC_000024.10 |
For example, a search on chromosome 1 in build GRCh37/hg19 would look like this:
A”>https://mastermind.genomenon.com/detail?mutation=NC_000004.11:g.94508323G>A
Searching by genomic coordinates will list references for variants mapped to alternate transcripts. We recommend adding the gene of interest as another search term to reduce off-target matches.