Before curated content becomes available in Mastermind, clinical genomic scientists review each article for evidence, ensure that the variant nomenclature is accurate and based on the canonical transcript, and apply ACMG interpretation criteria to the summarized evidence. The curated data then undergoes an extensive secondary QA review process before it is added to the Mastermind database. Our SOP for curated content can be found within the application (Genomenon Sequence Variant Interpretation Standards) or here.