Mastermind
Genomic Search Engine
The World’s Most Comprehensive Database of Genomic Literature
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Mastermind uses AI-driven genomics to accelerate variant interpretation, providing immediate insight into the full text of millions of scientific articles. Mastermind prioritizes your search results by clinical relevance and finds what you are looking for 5-10 times faster.
MASTERMIND IS…
FASTER
Quickly find all relevant articles for your specific search criteria, covering every disease, therapy, phenotype, gene, and variant.
SMARTER
Find hidden data and prioritize your results with intelligent tools that bring the most relevant articles to the top for review.
MORE COMPREHENSIVE
Search beyond title and abstract into the complete text of every published genomic paper, including supplemental data.
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Rady Children’s Institute for Genomic Medicine uses Mastermind
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Mastermind Explores Genomic Associations
Mastermind identifies every Genomic Association in the medical evidence, drawing informative connections between genes, variants, diseases, phenotypes, therapies, copy number variations (CNVs), and categorical keywords to inform both clinical care and drug discovery. Users can find, connect, explore, and understand the links between genomic concepts of interest in Mastermind’s intuitive literature search interface.
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HOW DOES MASTERMIND COMPARE?
A Side-by-Side Summary
In just 3 years, Mastermind surpassed the two primary sources of genomic literature, and we continue to add new data weekly! Here is a snapshot comparison.
| Mastermind | HGMD | ClinVar | |
|---|---|---|---|
| Genes | 19,346 | 15,493 | 17,213 |
| Variants | 23,705,021 | over 456,000 | 1,818,971 |
| Germline Variants | YES | YES | YES |
| Somatic Variants | YES | NO | YES |
| Journals | 36,305 | 3,100 | 3,792 |
| Full-Text Articles Indexed | 9,342,310 | 72,987 | 108,063 |
| Supplemental Datasets Indexed | 3,182,337 | N/A | N/A |
| Update Schedule | Weekly | Quarterly | Weekly |
| Free Version Content | Up to Date | 3 Years Old | Up to Date |
| Interpretation Criteria | ACMG/AMP | Own Criteria | ACMG/AMP |
| ACMG Gene Curation Parameters | YES | NO | NO |
| Clinical Exome Genes Curated based on ClinGen recommendations | YES | NO | NO |
Sources:
http://www.hgmd.cf.ac.uk/ac/stats.php
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5429360/
https://www.oncokb.org/
https://cancer.sanger.ac.uk/cosmic/curation
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323903/
https://www.ncbi.nlm.nih.gov/clinvar/submitters/
ftp://ftp.ncbi.nlm.nih.gov/pub/clinvar/tab_delimited/
https://www.qiagenbioinformatics.com/products/human-gene-mutation-database/1673-2/