Mastermind
Genomic Search Engine

The World’s Most Comprehensive Database of Genomic Literature



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Find the Most Evidence with Your New Search Companion
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Mastermind uses AI-driven genomics to accelerate variant interpretation, providing immediate insight into the full text of millions of scientific articles. Mastermind prioritizes your search results by clinical relevance and finds what you are looking for 5-10 times faster.

MASTERMIND WILL…


<strong>REDUCE TURNAROUND TIME</strong>

REDUCE TURNAROUND TIME

Quickly identify and review the empirical evidence, clinically prioritized with insight into each article to speed variant interpretation

<strong>INCREASE DIAGNOSTIC YIELD</strong>

INCREASE DIAGNOSTIC YIELD

Mastermind has 100X more genomic evidence and 20X more variants than other sources to help you find relevant articles and upgrade VUS calls

<strong>ACCELERATE THROUGHPUT</strong>

ACCELERATE THROUGHPUT

Scale your caseload and reduce the risk of missing a patient diagnosis —save 60-90 minutes per VUS search on average with Mastermind

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Rady Children’s Institute for Genomic Medicine uses Mastermind

Read the inspiring story of how this world-class institute used Mastermind to make a life-changing diagnosis for a sick newborn.


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Mastermind Explores Genomic Associations


Mastermind identifies every Genomic Association in the medical evidence, drawing informative connections between genes, variants, diseases, phenotypes, therapies, copy number variations (CNVs), and categorical keywords to inform both clinical care and drug discovery. Users can find, connect, explore, and understand the links between genomic concepts of interest in Mastermind’s intuitive literature search interface.

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HOW DOES MASTERMIND COMPARE?


A Side-by-Side Summary

In just 3 years, Mastermind surpassed the two primary sources of genomic literature, and we continue to add new data weekly! Here is a snapshot comparison.

 MastermindHGMDClinVarCOSMIC
Genes19,97712,77211,505719
Variants
14,778,187344,0121,036,770N/A
Germline VariantsYESYESYESNO
Somatic VariantsYESNOYESYES
Journals34,3893,6933,372N/A
Full-Text Articles Indexed8,337,45586,00086,75628,175
Supplemental Datasets Indexed3,017,170N/AN/AN/A
Update ScheduleWeeklyQuarterlyWeeklyQuarterly
Free Version ContentUp to Date3 Years OldUp to DateUp to Date
Interpretation CriteriaACMG/AMPOwn CriteriaACMG/AMPAMP

Sources:

http://www.hgmd.cf.ac.uk/ac/stats.php
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7497289/
https://www.oncokb.org/
https://cancer.sanger.ac.uk/cosmic/curation
https://cosmic-blog.sanger.ac.uk/Release-v94/
https://www.ncbi.nlm.nih.gov/clinvar/submitters/
ftp://ftp.ncbi.nlm.nih.gov/pub/clinvar/tab_delimited/var_citations.txt
http://www.hgmd.cf.ac.uk/ac/introduction.php?lang=english
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7497289/
https://ftp.ncbi.nlm.nih.gov/pub/clinvar/tab_delimited/variant_summary.txt.gz
https://cancer.sanger.ac.uk/cosmic/release_notes/
http://www.hgmd.cf.ac.uk/ac/index.php

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