Mastermind has added ClinVar
Discover 15x more variants than ClinVar and eliminate the bottleneck of manual curation
Mastermind Genomic Search Engine
FASTEST
Find all relevant articles for your specific search criteria, covering every gene, variant, CNV, disease, phenotype, therapy, and categorical keyword. No more ctrl+F.
SMARTEST
Updated weekly, you can find hidden data and prioritize your results with intelligent tools that bring the most relevant articles to the top for review. Even smarter – now with ClinVar.
MOST COMPREHENSIVE
Search beyond title and abstract into the complete full text of every published genomic paper, including supplemental data. All the charts. All the figures.
Plans to fit your needs.
Whether you’re an academic, or part of a global genetics lab, we’ve got solutions for everyone.
MASTERMIND BASIC EDITION
Ideal for students and always free. Start with a complimentary trial of Mastermind Professional Edition. No credit card required and we’ll email the details to get started.
MASTERMIND PROFESSIONAL EDITION
Dive deeper into the published genomic literature with enhanced features including ACMG/AMP classification, supplemental datasets, CNVs, creating alerts and more.
Using Mastermind enhances our ability to provide clinicians at the bedside with important relevant information about known treatments and interventions.
SEARCH EXAMPLE: ENPP1 and p.P305T
ClinVar is a freely accessible, public archive of information about genetic variations observed in individuals with or without a phenotype designed for variant interpretation and clinical practice. This entire body of aggregated data is now fully integrated into the Mastermind Genomic Search Engine. As a result, you can:
• Save time by searching the entire body of scientific literature all in one place
• Discover more clinically actionable insights not found in ClinVar
• Support clinical decision-making with the most comprehensive source of genomic evidence available
HOW DOES MASTERMIND COMPARE?
A Side-by-Side Summary
In just 3 years, Mastermind surpassed the two primary sources of genomic literature, and we continue to add new data weekly! Here is a snapshot comparison.
| Mastermind | HGMD | ClinVar | |
|---|---|---|---|
| Genes | 19,340 | 15,493 | 16,879 |
| Variants | 22,632,323 | 410,743 | 1,669,429 |
| Germline Variants | YES | YES | YES |
| Somatic Variants | YES | NO | YES |
| Journals | 35,876 | 3,100 | 3,702 |
| Full-Text Articles Indexed | 9,047,466 | 72,987 | 105,450 |
| Supplemental Datasets Indexed | 3,166,515 | N/A | N/A |
| Update Schedule | Weekly | Quarterly | Weekly |
| Free Version Content | Up to Date | 3 Years Old | Up to Date |
| Interpretation Criteria | ACMG/AMP | Own Criteria | ACMG/AMP |
Sources:
http://www.hgmd.cf.ac.uk/ac/stats.php
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5429360/
https://www.oncokb.org/
https://cancer.sanger.ac.uk/cosmic/curation
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323903/
https://www.ncbi.nlm.nih.gov/clinvar/submitters/
ftp://ftp.ncbi.nlm.nih.gov/pub/clinvar/tab_delimited/
https://www.qiagenbioinformatics.com/products/human-gene-mutation-database/1673-2/