Mastermind has added ClinVar

Discover 15x more variants than ClinVar and eliminate the bottleneck of manual curation

THE WORLD’S MOST COMPREHENSIVE SOURCE OF GENOMIC EVIDENCE

Mastermind Genomic Intelligence Platform


Mastermind Genomic Intelligence Platform
FASTEST

Find all relevant articles for your specific search criteria, covering every gene, variant, CNV, disease, phenotype, therapy, and categorical keyword. No more ctrl+F.

SMARTEST

Updated weekly, you can find hidden data and prioritize your results with intelligent tools that bring the most relevant articles to the top for review. Even smarter – now with ClinVar.

MOST COMPREHENSIVE

Search beyond title and abstract into the complete full text of every published genomic paper, including supplemental data. All the charts. All the figures.

Plans to fit your needs.

Whether you’re an academic, or part of a global genetics lab, we’ve got solutions for everyone.


MASTERMIND BASIC EDITION

Ideal for students and always free. Start with a complimentary trial of Mastermind Professional Edition. No credit card required and we’ll email the details to get started.

MASTERMIND PROFESSIONAL EDITION

Dive deeper into the published genomic literature with enhanced features including ACMG/AMP classification, supplemental datasets, CNVs, creating alerts and more.

Plans to fit your needs.

Using Mastermind enhances our ability to provide clinicians at the bedside with important relevant information about known treatments and interventions.


Stephen Kingsmore, MD, DSc <br> President and CEO Rady Children’s Institute for Genomic Medicine
Stephen Kingsmore, MD, DSc
President and CEO Rady Children’s Institute for Genomic Medicine

SEARCH EXAMPLE: ENPP1 and p.P305T

ClinVar is a freely accessible, public archive of information about genetic variations observed in individuals with or without a phenotype designed for variant interpretation and clinical practice. This entire body of aggregated data is now fully integrated into the Mastermind Genomic Intelligence Platform. As a result, you can:

• Save time by searching the entire body of scientific literature all in one place
• Discover more clinically actionable insights not found in ClinVar
• Support clinical decision-making with the most comprehensive source of genomic evidence available

HOW DOES MASTERMIND COMPARE?


A Side-by-Side Summary

In just 3 years, Mastermind surpassed the two primary sources of genomic literature, and we continue to add new data weekly! Here is a snapshot comparison.

MastermindHGMDClinVar
Genes19,34618,95417,381
Variants
24,237,214over 456,0001,846,066
Germline VariantsYESYESYES
Somatic VariantsYESNOYES
Journals36,4493,1003,860
Full-Text Articles Indexed9,314,08072,987110,312
Supplemental Datasets Indexed3,167,871N/AN/A
Update ScheduleWeeklyQuarterlyWeekly
Free Version ContentUp to Date3 Years OldUp to Date
Interpretation CriteriaACMG/AMPOwn CriteriaACMG/AMP
ACMG Gene Curation ParametersYESNONO
Clinical Exome Genes Curated based on ClinGen recommendationsYESNONO

Sources:
http://www.hgmd.cf.ac.uk/ac/stats.php
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5429360/
https://www.oncokb.org/
https://cancer.sanger.ac.uk/cosmic/curation
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323903/
https://www.ncbi.nlm.nih.gov/clinvar/submitters/
ftp://ftp.ncbi.nlm.nih.gov/pub/clinvar/tab_delimited/
https://www.qiagenbioinformatics.com/products/human-gene-mutation-database/1673-2/

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