Mastermind
Genomic Search Engine

The World’s Most Comprehensive Database of Genomic Literature



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Mastermind accelerates variant interpretation with immediate insight into the full text of millions of scientific articles. Prioritize your search results by clinical relevance and find what you are looking for 5-10 times faster.

MASTERMIND IS…


<strong>FASTER</strong>

FASTER

Quickly view clinically prioritized search results, with genomic insight into each article to speed clinical interpretation and genomic research.

<strong>MORE COMPREHENSIVE</strong>

MORE COMPREHENSIVE

Search beyond title and abstract into the complete text of every published genomic paper covering every disease, gene, and variant.

<strong>EMINENTLY SCALABLE</strong>

EMINENTLY SCALABLE

Eliminate the bottleneck of manual curation and stay up to date on the latest articles as Mastermind is updated weekly with newly published papers.

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WHAT IS MASTERMIND?


Mastermind is a comprehensive search platform to help you identify and analyze genetic evidence found across the complete corpus of scientific articles, powered by our Genomic Language ProcessingTM (GLP) algorithm and genomic literature database.

 

Full-Text Publications

&

Mastermind Database

The search results are prioritized based on clinical relevance of the article’s content and is designed to help you interpret variants, find and verify disease associations, and accelerate your genomic analysis.

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Compare Mastermind Basic, Professional, and Enterprise Editions


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MASTERMIND BENEFITS


COMPREHENSIVE COVERAGE

Never Miss an Important Paper
Search the most comprehensive and up-to-date database of full-text genomic articles by disease, gene, variant and/or keyword.

BIG-PICTURE LANDSCAPE

Start with a Comprehensive View
Visualize the evidence with a graphical view of article coverage and the variant landscape across the gene.

FOCUS ON CLINICAL RELEVANCE

Eliminate Non-Relevant Results
Prioritize search results by clinical relevance to put the most pertinent results at the top of the list.

FASTER, DEEPER INSIGHT INTO THE EVIDENCE

Choose the Right Article Quickly
Glean deep insight into the genes, variants, and hundreds of keywords contained in each article.

FILTER BY ACMG & AMP CRITERIA

Expedite Pathogenicity Interpretation
Filter your results by ACMG and AMP guidelines, clinical significance, and/or functional implications.

SEARCH BEYOND MASTERMIND

Search Companion for Chrome
Get Mastermind article counts and links when searching Google, Google Scholar, HGMD, and other databases. LEARN MORE

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MASTERMIND FEATURES


Powerful Capabilities to Drive Faster Clinical Interpretation

Clinically Relevant Search Results

Mastermind provides clinically relevant evidence by analyzing the 30 million articles in PubMed, identifying the articles with genomic content, and indexing the full text of those articles. Unlike other search engines, your search results won’t be cluttered with articles from journals on chemistry, material sciences, patents, or legal publications and will be prioritized by clinical and functional significance.

MASTERMIND FEATURES



Immediate Insight Into Every Article

See the number of times the gene or variant you specified is cited in each article, helping you quickly narrow your search to articles with the richest content.

MASTERMIND FEATURES



Deeper Insight with Full Text Matches

Dive deeper into your searches to see the full text sentence matches for each gene and variant. This valuable feature provides time-saving insight to help you select the right articles to focus on.

MASTERMIND FEATURES



ACMG, AMP, and Clinical Category Filters

Filter your search results by ACMG and AMP criteria, clinical categories (such as functional studies, population data, or pedigrees), and keywords found within each article (such as prognosis, diagnosis, therapy, mechanism of action and inheritance patterns) with Mastermind Professional Edition.

MASTERMIND FEATURES



Mastermind Alerts

Set up alerts for new genomic articles and publications that match your disease, gene, or variant and get an email when new evidence is added to Mastermind.

MASTERMIND FEATURES

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HOW DOES MASTERMIND COMPARE?


A Side-by-Side Summary

In just 3 years, Mastermind surpassed the two primary sources of genomic literature, and we continue to add new data weekly! Here is a snapshot comparison.

 MastermindHGMDCOSMIC
Genes32,00010,914200
Variants
4,900,000256,070408,000
Germline VariantsYESYESNO
Somatic VariantsYESNOYES
Journals32,0003,000N/A
Full-Text Articles Indexed6,700,00057,00026,878
Supplemental Datasets Indexed500,00029,000N/A
Update ScheduleWeeklyQuarterlyQuarterly
Free Version ContentUp to Date4 Years OldUp to Date
Interpretation CriteriaACMG/AMPOwn CriteriaAMP

Sources:
Stenson, Peter D. et al. “The Human Gene Mutation Database: Towards a Comprehensive Repository of Inherited Mutation Data for Medical Research, Genetic Diagnosis and next-Generation Sequencing Studies.” Human Genetics 136.6 (2017): 665–677. PMC. Web. 11 July 2018.

http://www.hgmd.cf.ac.uk/ac/stats.php

https://cancer.sanger.ac.uk/cosmic/release_notes/

 

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