Mastermind
Genomic Search Engine
Genomic Search Engine
Empowering variant scientists with the most comprehensive evidence
SEARCH MASTERMIND
Are you confident that you have all the evidence
you need for variant interpretation?
you need for variant interpretation?
A 2020 Study reported that laboratories disagreed on a variant’s classification 46% of the time, with 23% of those discrepancies being clinically impactful
The cause of these discrepancies is the lack of genomic evidence critical to diagnosis
Incomplete genomic evidence puts clinical diagnosis at risk
Legacy Nomenclature Makes Evidence Hard to Find
There are 172 unique ways authors describe the CFTR p.508del (deletion) variant, from 34,091 mentions to single mentions
Data is Hidden in the Body and Supplemental Text
Fewer than 6% of variants are identified in the title or abstract, the remainder present in the full-text or supplemental files
Assertions are Not Supported by Evidence
Google Scholar, ClinVar, and PubMed can miss evidence for up to 70% of clinically encountered variants
Incomplete genomic evidence puts patients at risk
One paper can change everything
Read the inspiring story of how Rady Children’s Institutefor Genomic Medicine used Mastermind to make a
life-changing diagnosis for a sick newborn
READ FITZ'S STORY
Find everything you are looking for 5-10 times faster with Mastermind
INCREASE DIAGNOSTIC YIELD
Accelerate Time-to-Results
REDUCE TURNAROUND TIME
100X More Content
20X More Variants
ACCELERATE THROUGHPUT
Scale as Caseload Grows
Mastermind Integrations
CHOOSE THE RIGHT PLAN FOR YOU. COMPARE MASTERMIND BASIC, PROFESSIONAL, AND ENTERPRISE EDITIONS
HOW DOES MASTERMIND COMPARE?
A Side-by-Side Summary
| Mastermind | HGMD | ClinVar | |
|---|---|---|---|
| Genes | 19,306 | 14,470 | 11,702 |
| Variants | 22,140,346 | 398,641 | 1,538,444 |
| Germline Variants | YES | YES | YES |
| Somatic Variants | YES | NO | YES |
| Journals | 35,686 | 3,100 | 3,555 |
| Full-Text Articles Indexed | 8,904,722 | 72,987 | 95,007 |
| Supplemental Datasets Indexed | 3,090,690 | N/A | N/A |
| Update Schedule | Weekly | Quarterly | Weekly |
| Free Version Content | Up to Date | 3 Years Old | Up to Date |
| Interpretation Criteria | ACMG/AMP | Own Criteria | ACMG/AMP |