Mastermind
Genomic Search Engine
The World’s Most Comprehensive Database of Genomic Literature
GET MASTERMIND
Mastermind accelerates variant interpretation with immediate insight into the full text of millions of scientific articles. Prioritize your search results by clinical relevance and find what you are looking for 5-10 times faster.
MASTERMIND IS…
FASTER
Quickly view clinically prioritized search results, with genomic insight into each article to speed clinical interpretation and genomic research.
MORE COMPREHENSIVE
Search beyond title and abstract into the complete text of every published genomic paper covering every disease, gene, and variant.
EMINENTLY SCALABLE
Eliminate the bottleneck of manual curation and stay up to date on the latest articles as Mastermind is updated weekly with newly published papers.
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WHAT IS MASTERMIND?
Mastermind is a comprehensive search platform to help you identify and analyze genetic evidence found across the complete corpus of scientific articles, powered by our Genomic Language ProcessingTM (GLP) algorithm and genomic literature database.
Full-Text Publications
&
Mastermind Database
The search results are prioritized based on clinical relevance of the article’s content and is designed to help you interpret variants, find and verify disease associations, and accelerate your genomic analysis.
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Choose the Right Plan for You
Compare Mastermind Basic, Professional, and Enterprise Editions
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MASTERMIND BENEFITS
COMPREHENSIVE COVERAGE
Never Miss an Important Paper
Search the most comprehensive and up-to-date database of full-text genomic articles by disease, gene, variant and/or keyword.
BIG-PICTURE LANDSCAPE
Start with a Comprehensive View
Visualize the evidence with a graphical view of article coverage and the variant landscape across the gene.
FOCUS ON CLINICAL RELEVANCE
Eliminate Non-Relevant Results
Prioritize search results by clinical relevance to put the most pertinent results at the top of the list.
FASTER, DEEPER INSIGHT INTO THE EVIDENCE
Choose the Right Article Quickly
Glean deep insight into the genes, variants, and hundreds of keywords contained in each article.
FILTER BY ACMG & AMP CRITERIA
Expedite Pathogenicity Interpretation
Filter your results by ACMG and AMP guidelines, clinical significance, and/or functional implications.
SEARCH BEYOND MASTERMIND
Search Companion for Chrome
Get Mastermind article counts and links when searching Google, Google Scholar, HGMD, and other databases. LEARN MORE
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MASTERMIND FEATURES
Powerful Capabilities to Drive Faster Clinical Interpretation
Clinically Relevant Search Results
Mastermind provides clinically relevant evidence by analyzing the 30 million articles in PubMed, identifying the articles with genomic content, and indexing the full text of those articles. Unlike other search engines, your search results won’t be cluttered with articles from journals on chemistry, material sciences, patents, or legal publications and will be prioritized by clinical and functional significance.
Immediate Insight Into Every Article
See the number of times the gene or variant you specified is cited in each article, helping you quickly narrow your search to articles with the richest content.
Deeper Insight with Full Text Matches
Dive deeper into your searches to see the full text sentence matches for each gene and variant. This valuable feature provides time-saving insight to help you select the right articles to focus on.
ACMG, AMP, and Clinical Category Filters
Filter your search results by ACMG and AMP criteria, clinical categories (such as functional studies, population data, or pedigrees), and keywords found within each article (such as prognosis, diagnosis, therapy, mechanism of action and inheritance patterns) with Mastermind Professional Edition.
Mastermind Alerts
Set up alerts for new genomic articles and publications that match your disease, gene, or variant and get an email when new evidence is added to Mastermind.
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HOW DOES MASTERMIND COMPARE?
A Side-by-Side Summary
| Mastermind | HGMD | ClinVar | COSMIC | |
|---|---|---|---|---|
| Genes | 33,709 | 11,100 | 32,937 | 238 |
| Variants | 6,826,561 | 289,346 | 804,094 | 408,000 |
| Germline Variants | YES | YES | YES | NO |
| Somatic Variants | YES | NO | YES | YES |
| Journals | 33,147 | 3,100 | 3,180 | N/A |
| Full-Text Articles Indexed | 7,606,650 | 72,987 | 78,411 | 27,496 |
| Supplemental Datasets Indexed | 1,714,138 | 29,000 | N/A | N/A |
| Update Schedule | Weekly | Quarterly | Weekly | Quarterly |
| Free Version Content | Up to Date | 4 Years Old | Up to Date | Up to Date |
| Interpretation Criteria | ACMG/AMP | Own Criteria | ACMG/AMP | AMP |
http://www.hgmd.cf.ac.uk/ac/stats.php
https://www.ncbi.nlm.nih.gov/clinvar/submitters/
https://cancer.sanger.ac.uk/cosmic/release_notes/
Tate JG, Bamford S, Jubb HC, et al. COSMIC: the Catalogue Of Somatic Mutations In Cancer. Nucleic Acids Res. 2019;47(D1):D941-D947. doi:10.1093/nar/gky1015