Does Mastermind differentiate between positive and negative associations for diseases and genes or diseases and variants?

No. Mastermind searches for all mentions of a disease, gene, or variant, but does not draw conclusions about the nature of the association between the disease and variant or gene. We leave that to the experienced clinical genomic scientists who utilize the application to obtain a comprehensive source of evidence. The Prognosis keywords found under the Clinical Significance category are often useful for prioritizing papers related to the impact of the gene and/or variant in the context of disease.