From the Lab to the Clinic: Where Generative AI for Biomedicine Holds Up and Where it Breaks Down

John Quackenbush, Professor of Computational Biology and Bioinformatics at Harvard T.H. Chan School of Public Health and Mark Kiel, Founder and CSO of Genomenon joined us for a candid fireside conversation on use of AI in biomedicine. Bringing optimism about AI’s potential into direct contact with skepticism about what it can truly prove, this discussion put two distinct perspectives into dialogue - pressure testing what AI can truly contribute to biomedical research and clinical decision-making.

In this conversation, John and Mark covered how evidence is gathered, processed, and structured - and how it’s applied to decisions in research, development, and clinical practice.

Key questions we covered include:

  • Is generative AI advancing biomedical knowledge, or just industrializing confirmation bias?
  • Are we deploying generative AI in the clinic before we’ve agreed on what counts as evidence?
  • If an “insight” can’t be traced back to primary sources, is it useful or too risky for hypothesis generation?
  • Have we mistaken fluency for understanding - do models generate genuine insight, or do we project insight onto them?
  • Will generative AI reduce uncertainty in biomedicine or mainly repackage it faster?

This session will give you a clear, practical view of where generative AI actually helps across drug development cycles - what it can accelerate (and what it can’t), where the risks show up, and what defensible validation looks like before it informs decisions.

Who should watch:

This webinar was designed for pharma and biotech professionals applying AI across the drug development cycle, including teams in: 

  • Discovery & Translational Science
  • Clinical Development & Trial Strategy
  • Medical Affair & Real World Evidence
  • Bioinformatics & Data Science 

If you are making high-stakes decisions, and want a realistic understanding of what generative AI can and cannot support, this session is for you.

Watch the recording today!

Speaker
John Quackenbush, PhD
Professor, Computational Biology and Bioinformatics, Department of Biostatistics


John Quackenbush is Professor of Computational Biology and Bioinformatics in the Department of Biostatistics at the Harvard TH Chan School of Public Health and Professor at the Dana-Farber Cancer Institute. John’s PhD was in Theoretical Physics but a fellowship to work on the Human Genome Project led him through the Salk Institute, Stanford University, and The Institute for Genomic Research (TIGR), before joining Harvard in 2005.


John’s research uses massive data to probe how many small genetic and other effects combine to influence our health and risk of disease. Key to his approach is modeling gene regulatory networks and understanding how these networks change between health and disease, over time, as a function of sex and gender, and between individuals. His more than 350 published papers have more than 105,000 citations and his “NetZoo” software tools have tens of thousands of downloads. Among his honors is recognition in 2013 as a White House Open Science Champion of Change. In 2012 he founded Genospace, a precision medicine software company that was sold to Hospital Corporation of America in 2017. In 2022, he was elected to the National Academy of Medicine.

Speaker
Mark J. Kiel, MD, PhD
Chief Scientific Officer & Co-Founder


Dr. Mark Kiel is the co-founder and chief scientific officer at Genomenon, where he oversees the company's scientific direction and product development. Mark received his MD/PhD in Clinical Pathology at the University of Michigan. He founded Genomenon to address the challenge of connecting researchers with evidence in the literature to help diagnose and treat patients with rare genetic diseases and cancer.

Genomenon

Genomenon is a leading literature-derived genomic intelligence and real world evidence company supporting pharmaceutical and clinical organizations in rare disease and precision oncology. By combining clinically aware artificial intelligence with deep scientific expertise, Genomenon transforms fragmented biomedical literature into structured, actionable insights that improve diagnosis and accelerate precision therapeutics development. Genomenon’s solutions are trusted by more than 250 clinical diagnostic laboratories and have supported over 75 drug development programs across global pharma teams. Headquartered in Ann Arbor, Michigan, Genomenon operates with a globally distributed team dedicated to saving and improving lives by making biomedical information actionable.

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