Using Somatic Variant Curation to Interpret Complex Cancer Genomic Profiles

Genomenon’s Clinical Knowledgebase (CKB) is the world’s leading curated somatic variant database used by premier oncology labs to interpret even the most complex cancer genomic profiles. As a centralized hub for cancer variant information, CKB provides valuable information that connects cancer variants to therapies and clinical trials, empowering you in your research and clinical practice.

Genomenon acquired CKB this spring, enabling us to provide an unprecedented understanding of the genome, with insights now covering both germline and somatic variants. 

Join us for this webinar to hear from CKB’s experts on how the tool can be used for clinical applications, increasing confidence in the completeness and accuracy of information related to a patient’s tumor genomic profile and ensuring the best-informed clinical decision is made for a patient.

 

In this session, you will learn:  

  • The ways CKB can be used to interpret cancer variants and navigate variant relationships
  • How CKB supports personalized medicine by identifying appropriate therapies and clinical trials through category-variant relations.  
  • Use cases when CKB and Mastermind can be used together, providing a comprehensive understanding of all cancer genetic profiles, including germline and somatic variants.

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Panelist
Cara Statz, PhD
Manager, Oncology Curation

Cara has nearly 10 years of experience in clinical genomics, and has been contributing her expertise to interpretation of literature-based data related to genomic variants and targeted therapies in oncology and curation of those data into the Cancer Knowledgebase (CKB) since 2015. In addition to her curation-related activities, Cara regularly liaises with users to provide additional insights into the capabilities of CKB. She received her PhD from UCONN in genetics and genomics and has prior experience as a clinical research associate, and leverages her clinical and research expertise in her work on CKB, with the ultimate goal of enabling better patient outcomes.

Panelist
Joe Jacher
Field Application Scientist

Joe provides technical support and training to Mastermind users at all levels. With a background as a clinical genetic counselor and in marketing and sales roles in the clinical laboratory space, he brings a patient-centric mindset to help end the diagnostic odyssey for patients globally.

Genomenon

The Real-world Evidence to validate a drug target, identify trial-eligible patients, or change a diagnosis already exists. It is buried in 39 million biomedical articles, locked behind paywalls and supplemental files most researchers never find.

Genomenon closes that gap. Fit-for-purpose AI-powered search reads 11.2 million full-text papers and 3.7 million supplemental datasets. Eighty expert scientific curators validate every finding. The result is structured, traceable, regulatory-grade Real-World Evidence at the genetic variant and patient level. Loxo@Lilly used Genomenon to add 73 variants to the RET label. In a head-to-head, Genomenon identified 83% more rare disease patients than ChatGPT plus OpenEvidence.

250+ diagnostic labs and 75 biopharma programs rely on Genomenon as the evidence layer behind precision medicine.

The World’s Most Comprehensive Source of Genomic Evidence

Mastermind accelerates variant interpretation with immediate insight into the full text of millions of scientific articles. Prioritize your search results by clinical relevance and find what you are looking for 5-10 times faster

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Every Missing Genetic Variant is a Patient Your Label Doesn't Reach
  • Rare disease and precision oncology programs rely on evidence fragmented across millions of published articles and supplemental datasets.
  • Genomenon builds the custom real-world evidence your program needs.
  • AI-powered search. Expert scientific curation.
  • The result: a broader label, more eligible patients, and a regulatory filing your team can defend.
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