Can I filter out certain types of articles or keywords?
We use a filter-in approach to ensure maximal sensitivity and no articles get missed. Where a filter-out approach is prone to discarding potentially relevant articles, utilizing the Filter Categories in conjunction with phenotypes/diseases/therapies/text leverages the power of GLP and Mastermind’s Relevancy algorithm. The filter-in approach enables prioritization of the literature and presents you with information …
Is there a way to filter literature results by somatic vs germline?
Mastermind has categorical keywords for “somatic” and “germline” found under ACMG interpretation>Inheritance pattern that help prioritize more relevant content. In addition, including diseases or phenotypes in the search is a particularly useful tool for filtering articles.
Can Mastermind be used to identify mutational hotspots?
Yes. Mastermind is ideal for identifying evidence of hotspots in genes. The Variant Diagram plot is a visual representation of variants published for the gene in question, as well as the relative number of associated articles. Using this feature, you can determine at a glance which regions are highly variable. This plot updates whenever your …
How should I cite Mastermind in my paper?
When referring to the use of Mastermind within a sentence, please use the following text: “Mastermind Genomic Search Engine (https://www.genomenon.com/mastermind)”
Where does your population data come from?
Population data for curated variants is based on data from gnomAD v2.1.1.
Does Mastermind have curated content for every variant for a curated gene?
Curated content is available for published variants in the canonical transcript of a curated gene. For variants that are unpublished or for which the published information provides no useful information for classification, curated content may not be available.